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SYNVISC INJECTIONS (Hylan G-F 20)
Synvisc is a treatment for osteoarthritis (OA) pain of the knee in patients who have failed to find relief by conservative nonpharmalogic therapy and simple analgesics (example: acetaminophen). Synvisc injection was developed and is manufactured by the Genzyme Corporation. Synvisc provides lubrication to the knee and acts as a "shock absorber" for the knee joint. Synvisc is simalar to synovial fluid that is found naturally in the joints and is made from a substance called hyaluronan that is found in normal joint fluid.
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How it is Given
Synvisc is injected by a health care professional directly into the knee joint three times, 7 days apart, over a period of 15 days (Day 1, 8, and 15). To get the best results from the injection, the health care professional will remove the diseased osteoarthritic synovial fluid from your knee prior to the Synvisc injection. It is injected into the knee to help restore the cushioning effect and lubrication of normal, healthy synovial fluid and helps reduce pain from osteoarthritis. This treatment is refered to as viscosupplementation.
Most patients feel the greatest pain relief 8 to 12 weeks after beginning treatment of Synvisc. Your doctor may suggest for you to temporarily avoid strenuous activity.
Synvisc should not be used if there is an infection or skin disease at the site of injection.
Temporary pain or swelling may occur in the affected joint after injection of Synvisc.
Avoid strenuous activity or prolonged (longer then an hour) weight-bearing activity (jogging, running, strenuous sport, lifting weights) for 48 hours following an injection of Synvisc unless you are otherwise directed by your doctor. Remember to keep Synvisc and all other medicines out of the reach of children. Never share your medications with others, and use Synvisc only as prescribed.
Side Effects
Synvisc is generally well tolerated with most patients but may not work for everyone. Most commonly reported side effects have been temporary pain, swelling, and/or fluid accumulation in the injected knee. If fluid accumulation is large and painful see your doctor immediately. Other side effects, yet rare, that may occur are side effects such as a rash or bruising at the injection site, headache or upset stomach. If you notice any other side effects that are unusual or bothersome that are not listed here contact and discuss with your doctor.
Notify your doctor and seek immediate medical attention if you experience an allergic reaction to Synvisc. Although rare, allergic reactions should be taken seriously and you should seek medical attention immediately. Symptoms of an allergic reaction are difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or an outbreak of hives.
It is not known if Synvisc effects or is harmful to women during pregnancy. It is also not known if Synvisc can be passed through breast milk. Discuss using Synvisc while pregnant or breast feeding with your doctor. Do not use Synvisc if you are pregnant or breast feeding without talking to your doctor first.
If you happen to miss a dose of Synvisc treatment contact your doctor.
An overdose of Synvisc is unlikely to threaten your life. Even so, if an overdose of Synvisc does occur or is suspected contact your doctor and seek immediate medical attention.
Who is a Candidate for Synvisc?
Synvisc is used to treat people who have not found pain relief using the methods of exercise, physical therapy, the use of heat (e.g. heat pad) or cold (e.g. ice packs), and/or acetominophen.
People that may want to consider Synvisc are those that are not recieving adequate pain relief from current treatment, cannot take asprin or other anti-inflammartory drugs like ibuprofen, are already taking multiple oral medications, and are not appropriate candidates for knee surgery.
It is shown that Synvisc is effective in all stages of Osteoarthritis, although most effective in less severe stages of this disease.
Consult your doctor about using Synvisc if you have have any allergies to birds or bird products, feathers, or egg products. If so, you may not be allegeable for the treatment of Synvisc.
What should I tell my doctor?
Notify your doctor if you have any allergies to birds or bird products, example: feathers, eggs, or poultry, or if you leg is swollen or infected before you begin treatment of Synvisc.
It is not known is Synvisc threatens your child if you are pregnant or are breast feeding. Discuss using Synvisc while pregnant or breast feeding with your doctor. Do not use Synvisc if you are pregnant or breast feeding without talking to your doctor first.
Discuss with your doctor the amount of excercise or strenuous activity you can do while using Synvisc. It is advised that you refrain from doing strenuous or prolonged activity (longer than 1 hour) for the first 48 hours following treatment of Synvisc unless otherwise directed by your doctor.
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