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How Does NeoVisc (Sodium Hyaluronate) Work? Patients with Osteoarthritis typically experience pain and loss of mobility because of changes to the internal environment of the affected joint within the knee. NeoVisc works as a viscosupplement by improving the natural viscosity and elasticity of synovial fluid that breaks down inside the knee, thereby increasing lubrication, joint mobility and decreasing pain. Intar-articular injections of NeoVisc is more simply understood if you think of it as putting oil on a rusty hinge.